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Wegovy comes in doses of 0.25, 0.5, 1.0, 1.7, and 2.4 milligrams, escalated every 4 weeks to a maintenance dose of 2.4 milligrams

Obesity is defined as a BMI of 30 or above, while a BMI of 25 or above is considered overweight

A recent trial that enrolled over 17,000 participants demonstrated that Wegovy reduced the risk of heart attack, stroke and cardiovascular disease by 20% compared to placebo

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Although the drug met its primary endpoint of achieving a statistically significant weight reduction compared to placebo, the results fell short of the 25% weight loss target that Novo had been pitching to investors

Receptor selectivity, tissue exposure, formulation, dose, timing, model choice, and safety signals all sit upstream