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In keratinocyte-based experiments, calcipotriol was shown to elevate IB levels and inhibit its IL-17 A-induced degradation, thereby reducing the expression of downstream NF-B target genes such as IL-8 and human -defensin 2 (HBD2) [213]

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For more information and inquiries about this advisory, kindly contact the FDA Center for Food Regulation Office and Research through email [email protected] indicating on the subject the concerned Advisory, or call (02)857-1900 local 8112

Proper clinical oversight includes review of medical history, medication interactions, cardiovascular risk, and ongoing monitoring