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Nat Rev Endocrinol (2010) 6(9):51525.10.1038/nrendo.2010.123 8 BrooksAJWoohJWTunnyKAWatersMJ

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40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways

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