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It has been shown that GLP-1 analogue exenatide could activate the human monocyte-derived macrophage towards M2 phenotype ( -/- mice with a concomitant upregulation of M2 marker CD163 ( +/- mice, a -cellspecific glucokinase haploinsufficient (Gck+/) diabetic model ( 2.2 The role of GLP-1 in innate-like T lymphocytes Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes that bridge the innate and adaptive immune systems ( 2.3 The role of GLP-1 in intestinal epithelial lymphocytes As a innate like lymphocytes, intestinal epithelial lymphocytes (IELs) patrol the lamina propria and play a critical role in host-bacteria interaction, wound healing, mucosal growth and regeneration, and inflammation ( -/- mice, while the numbers of CD4+ and CD8+ T cells and B cells in the spleen and lymph nodes had no differences ( 3 The role of GLP-1/GLP-R axis in related signal pathways GLP-1 is known to increase insulin secretion by cells under hyperglycemic conditions

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3.) Reduction in Inflammation and Cardiovascular Risk: GLP-1 medications have the added benefit of anti-inflammatory effects as it decreases the release of proinflammatory cytokines that lead to systemic inflammation and allowing for reperfusion of the microvasculature structures damaged by inflammation

However, some patients have anecdotally reported feeling irritable, anxious, or experiencing mood fluctuations