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For surgery, patients are typically advised to pause the medication for one week prior to the procedure to prevent complications with anesthesia and gastric emptying

Finally, gene set enrichment analysis of the differentially expressed genes were performed using the gost function from the g:Profiler R package (Raudvere et al

While these changes can be surprising, they arent harmful, and they dont happen to everyone taking Ozempic or similar GLP-1 medications

[1] The most frequently reported gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 patients) Diarrhoea (very common, affecting more than 1 in 10 patients) Vomiting (common to very common, depending on dose) Decreased appetite (very common) Constipation Abdominal pain or discomfort Dyspepsia (indigestion) Belching , which may occasionally have a sulphurous odour These symptoms typically occur because GLP-1 receptor agonists slow gastric emptyingthe rate at which food leaves the stomachand alter gastrointestinal motility

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SLC38A1 and SLC38A2 SLC38A1 (SNAT1) and SLC38A2 (SNAT2) are sodium-dependent neutral amino acid transporters that drive glutamine influx into cells 90