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Recently, researchers developed a translational pharmacokinetic and pharmacodynamic model by integrating in vitro and in vivo data in a mechanistic and quantitative manner, which revealed a dose-dependent reduction in the cardiac amyloid burdenoccurring within 4 months at 60 mg/kg and within 10 months at 10 mg/kg

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TRMA is also referred to as thiamine metabolism dysfunction syndrome 1 (THMD1)

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INTRODUCTION Prostate cancer has become the second leading cancer in men globally [1], accounting for 1.3 million new cases in 2018 [2]

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