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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

Another factor leading to muscle loss is rapid weight loss, which clinical trials show that people on semaglutide may experience

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Manufacturing Issues (618 months): Scale-up failures or supply chain disruptions