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Although Glp1r mRNA transcripts are detected in whole heart extracts such methods do not distinguish between vascular smooth muscle cells or atrial cardiomyocytes, there were technical difficulties in isolating pure cardiomyocyte populations from the ventricle without contamination of atrial cardiomyocytes isolated from neonatal mouse [36]

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demonstrated that central GLP-1 signaling plays an essential role in the regulation of arterial blood flow, heart rate, and insulin sensitivity [121]