Formulation Purity: Why Fillers Undermine the Goal Conventional probiotics often contain microcrystalline cellulose (MCC), magnesium stearate, and titanium dioxideinert excipients that improve manufacturing flow and shelf appearance
They can also watch for rarer, more dangerous risks, such as gallbladder inflammation, gallstones, and pancreatitis
Common Degradation Pathways: Oxidation (e.g., methionine residues) Deamidation (asparagine or glutamine residues) Aggregation due to hydrophobic interactions Impact: Generates multiple degradation products Leads to variability in analytical results Makes it difficult to distinguish true impurities from artifacts 3
Pain 11 , 24 (2015)
Form: Lyophilized Composite Powder
[4] Fan, Y., Marioli, M., & Zhang, K