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1 Thats encouraging, but its early-stage evidence, and Mounjaro doesnt replace any RA medication

Semaglutide is still protected under patent by its manufacturer Novo Nordisk, so the FDA hasnt approved any true generic equivalents yet

What could that be? In a way, your study found GLP-1s are, at times, working too well

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I was skeptical about something that could actually blunt my huge hunger and this has done it

Moreover, the pattern of signal bias first demonstrated in HEK293 cells was recapitulated when we expressed SNAP-GLP-1R in INS-1 832/3 cells in which the endogenous GLP-1R was deleted by CRISPR/Cas9 (Naylor et al., 2016), with lixisenatide showing a relative preference for internalisation compared to cAMP signalling (Figure 4C, Supplementary Figure 3A)