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After exposure to allergens, the nasal cavity locally produces specific IgE, which binds to the surface receptors of mast cells and basophils gathered in the nasal mucosa and reaches a sensitized state [10]

10.1016/0005-2787(80)90053-2 550 SoulagesJ

Oxidative stress, which is caused by an excessive amount of free radical production in the lungs, is a significant contributor to the damage to the pulmonary tissue [98]

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