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Monitoring and Dose Adjustments During Combination Therapy Starting tirzepatide while already taking metformin typically follows a standard dose-escalation protocol, beginning at the lowest dose and increasing gradually over weeks

Blesa, J., Trigo-Damas, I., Quiroga-Varela, A

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Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB

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Those with type 1 diabetes, severe kidney disease, or acute infections may not be suitable candidates without specialized endocrinology input