Your B12 regimen will differ based upon your goals and also your health at the start of treatment
Low levels of B12 may include fatigue, weakness, pale skin, neurological symptoms, mood changes, or gastrointestinal issues
S2CID 31599027
Consequently, it allows researchers to study isolated metabolic responses more accurately
While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency
However, significant improvements of analytical instrumentation in terms of sensitivity and stability are required to overcome the current limitations