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Comments: Subcutaneous semaglutide 1 mg / week: 13 % improvement in walking distance vs placebo (med 26.4 m / avg 39.9 m) Improved quality of life (VascuQoL-6 and SF-36 questionnaires) Fewer rescue treatments vs placebo Improvement in ankle-brachial index (ABI) Modest weight loss of 4.1 kg with Semaglutide vs placebo Key benefits: Rapid benefit (from week 26) maintained over time (up to week 57) Improved performance on inclined treadmill Increased ABI, supporting a direct vascular benefit (anti-inflammatory action) Potential additional benefits: weight loss, cardiometabolic effects, renal benefits, major cardiovascular event reduction, heart failure benefits Limitations: Difficulty translating treadmill improvement to daily life activities Benefits may vary based on disease severity, functional demands, and patient expectations Study limited to diabetic patients Short-term evaluation of adverse major events Modest but statistically significant improvement in ABI warrants further mechanistic studies on PAD Other considerations: Weight loss and gastrointestinal effects may have revealed randomization, but unlikely to affect objective measures (walking distance or ABI) Other available medications: Pentoxifylline : Few benefits compared to placebo Cilostazol : Similar clinical improvement to Semaglutide Both increase walking distance without impact on cardiovascular health Get the latest clinical cases and breaking news delivered straight to your inbox!

Primary intention-to-treat analyses of laboratory outcomes consisted of residualized change models testing medication effects on posttreatment self-administration (g-ETOH and peak BrAC

The results revealed remarkable improvement in the PASI score (68.1% and 73.1%) in the first two groups of patients treated with balneophototherapy compared with the third treatment regimen

This hormone helps control blood sugar levels, reduces appetite, and makes the body more sensitive to insulin

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