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Reducing dietary fat intake during the initial treatment phase is the single most effective dietary modificationhigh-fat meals trigger stronger intestinal fluid secretion and accelerate bowel movements

Therefore for this group of drugs extraction is influenced by changes in protein binding more than by changes in hepatic blood flow

However, recent studies have also characterized previously unrecognized roles for tumor-draining lymph nodes (TDLNs) in cancer immunotherapy response, including acting as a reservoir for pre-exhausted CD8+ T cells and stem-like CD8+ T cells

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Montes M, Nielsen MM, Maglieri G, Jacobsen A, Hojfeldt J, Agrawal-Singh S et al

doi: 10.1371/journal.ppat.1000561 145 LiTHuangXYuanZWangLChenMSuFet al