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The thinking is that a smaller amount of the drug can still trigger its effects, but on a more modest scale

Furthermore, we prepared the citrate-capped AuNPs (ca.13 and 20 nm) for the comparison study, and the zeta potential of the citrate-capped AuNPs was negative at pH 3.6

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For quantification, calibrator samples were prepared by spiking standard solutions of the analyte to blank plasma which were analyzed according to the method

Higher doses may result in faster hunger reduction, but they should always be prescribed and monitored by a healthcare provider