If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase
Supplied as a lyophilized powder for reconstitution
In a recent phase 2 randomized trial, 9 weeks of low-dose semaglutide in 48 outpatient participants with alcohol use disorder led to reductions in some but not all measures of alcohol use and craving
doi: 10.2337/dc16-0691 29 DaviesMJBergenstalRBodeBKushnerRFLewinASkjthTVet al
This phenomenon may be partly explained by biological differences such as variations in sex hormone levels, pancreatic -cell composition, and gene expression patterns related to insulin secretion and glucose metabolism [49]
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