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By comparison, orlistat (Xenical) produced approximately 3-4 kg more weight loss than placebo over 12 weeks in its pivotal trials, and GLP-1 agonists produce 8-15 kg more than placebo

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The three receptors Retatrutide targets are: GLP-1 (Glucagon-Like Peptide-1) Receptors control appetite signaling in the brain and slow gastric emptying

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