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If you notice blood in your stools, significant unintentional weight loss beyond what is expected from the medication, or symptoms of anaemia such as extreme fatigue and pallor, these could indicate conditions requiring investigation beyond IBS and should be evaluated promptly

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Yes, when combined with a healthy diet and exercise

Error bars indicate standard deviation (SD)

Statistical Methods Change from baseline in SGRQ Total score and each component score were analyzed using analysis of covariance, with change from baseline as the response variable and with factors for treatment group, high-risk CV comorbidities (yes/no), background LABA use (yes/no), and baseline score as covariates

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