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[Abstract] J Chromatogr A

In the three human studies completed, the safety profile has been promising

reported that, different from in vitro assay, as l-cysteine is present in micromolar concentrations in the intracellular environment, the activity of -glutamyl phosphate reductase (GPR) encoded by PRO2 in eukaryotes or proA in prokaryotes must be shut off to allow -GC formation from -glutamyl phosphate [12]

The experiment was divided into two parts: Part 1, in which they were randomly divided into four groups: the WT group, the APP/PS1 group, the APP/PS1+ Dihexa (1.44 mg/kg) group, and the APP/PS1+ Dihexa (2.88 mg/kg) group, and Part 2, in which mice were divided into three groups: the APP/PS1 group, the Dihexa (2.88 mg/kg) group, and the Dihexa (2.88 mg/kg) + wortmannin (0.5 mg/kg) group

None of the animals were sacrificed for this study