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Moreover, given the contribution of various cellular processes in the pathogenesis of CP-induced AKI, using a combination of several modulators or identifying agents that can simultaneously modulate multiple targets may serve as an important strategy for developing future treatments

This benefit has been demonstrated most clearly early in the natural history of the disease in studies using metformin, sulfonylureas and insulin but is supported by more recent studies with other medication classes

Lifestyle factors profoundly influence oxidative stress levels

Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiles in sprague-dawley male rats