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Unlike short-term diet drugs, tirzepatide addresses appetite regulation at the hormonal level, which means many patients experience durable resultsbut the question of long-term use deserves a clear, evidence-based answer

A meta-analysis showed that treatment with a tumor necrosis factor-alpha (TNF-alpha) inhibitor, a first-line treatment for UC, was less likely to work well for people with BMIs in the obese range

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Nearly half of users discontinue within a year due to side effects, cost, supply issues, or not wanting lifelong medication

Read our compounded vs brand GLP-1 guide for the cost trade-offs