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It has been one of the most consistently studied peptides in research environments over the past two decades, examined for its interactions with vascular signaling networks, connective tissue pathways, and adaptive cellular communication
In a 2025 New England Journal of Medicine head-to-head study in adults with obesity but without diabetes, tirzepatide produced a mean 20.2 percent reduction in body weight at 72 weeks, compared with 13.7 percent for semaglutide
Here we synthesize efficacy data, safety signals, tolerability, and quality-of-life implications drawn from pivotal trials and expert commentary, and we highlight gaps where we still need long-term answers
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Published September 27, 2023
