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927 Transcriptional analysis indicates that the Hippo signaling pathway may be downstream of HDAC3, and overexpression of transcriptional regulator YAP or inhibition of the Hippo pathway both significantly reduce hepcidin levels

2020 Dec 8;10

The brain is particularly susceptible to oxidative stress due to its high oxygen demand, abundance of high-redox-active metals (such as iron and copper), and vulnerability of polyunsaturated fatty acids to oxidative damage, while the number of antioxidant factors is relatively limited [174, 175]