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This process, known as denaturation, is irreversible

Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives

doi: 10.2217/mmt-2018-0003 4 HahnHMLeeKGChoiWCheongSHMyungKBHahnHJ

Suh, KS et al (2016)

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Both, SGLT2 inhibitors and GLP1 receptor agonists, had similar effect on MACE reduction, but SGLT2 inhibitors have far more benefits in patients with heart failure