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A combination of lifestyle and behavioral changes are usually the first line of defense when treating individuals who are overweight or obese

Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]

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The complex structure of GLP-1R poses a challenge for drug development

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