Diabetes Obes Metab 2022
60 In a meta-analysis by Shi et al., GLP-1RAs significantly reduced AF events compared to metformin, sulfonylurea, insulin and non-sulfonylurea in patients with T2D and were associated with better outcomes compared to other medications
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However, therapeutic effects begin to diminish sooner, with blood glucose levels typically rising within 12 weeks of discontinuation
This has been reported with both tirzepatide and retatrutide, though it is likely related to the weight loss itself rather than the medication directly
In a study using cultured rat hippocampal neurons, pre-treatment of nerve cells with GLP-1 resulted in a weakened Ca 2+ response to glutamate and weakened membrane depolarization (46)
