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Mol Pharmacol 66:97105 [DOI] [PubMed] [Google Scholar] Gold SJ, Han MH, Herman AE, Ni YG, Pudiak CM, Aghajanian GK, Liu RJ, Potts BW, Mumby SM, Nestler EJ

Genomic biomarkers are considered here as providing merely a foundation for identifying inherited risks that intersect with broader (and clinically more relevant) proteomic and fluid markers

Oxidative stress, inflammation, and a decline in mitochondrial function are major contributors to this process

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In his Hippocratic Corpus, compiled centuries before the advent of precision medicine, Hippocrates had set up the foundations of what we would now call a personalized approach to healthcare, having done so even in the absence of the sophisticated diagnostic tools that are available today

Plasma levels of GHK-Cu decline roughly 60% between age 20 and age 60, which tracks closely with the body's decreasing ability to heal and regenerate tissue