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370 Two clinical trials suggested that lower-dose methazolamide (100200 mg daily) had similar prophylactic efficacy comparable to higher dose of acetazolamide (500 mg daily)

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389 (24): 2221 DOI: 10.1056/NEJMoa2307563 John Deanfield, A Michael Lincoff, Steven E Kahn, Scott S Emerson, Ildiko Lingvay, Benjamin M Scirica, Jorge Plutzky, Robert F Kushner, Helen M Colhoun, G Kees Hovingh, Signe Stensen, Peter E Weeke, Ole Kleist Jeppesen, Rafael Bravo, Chau-Chung Wu, Issei Komuro, Ferruccio Santini, Jran Hjelmesth, Miguel Urina-Triana, Silvio Buscemi, Donna H Ryan

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