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found that DMF can significantly ameliorate the stimulation of HSC induced by thioacetamide, which is related to its suppression of the inflammatory cascade and accumulation of Nrf2 to increase the expression of antioxidants (Figure 5) ( Liver sinusoidal endothelial cells (LSEC) act a pivotal part in the occurrence and development of liver injury, and their biological signals determine liver regeneration and fibrosis (Ruart et al., 2019)

Nrf2/ARE, Nuclear factor erythroid 2-related factor 2/Antioxidant response element

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Increased plasma acetate may contribute to this effect (1, 113)