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A phase 2 study of OSI-906 (linsitinib, an insulin-like growth factor receptor-1 inhibitor) in patients with asymptomatic or mildly symptomatic (non-opioid requiring) metastatic castrate resistant prostate cancer (CRPC)

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IGF-1 LR3, by extending IGF-1like signaling, is used to assess how sustained pathway activation affects the timing and quality of differentiation events

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doi: 10.1080/01140671.2017.1314307 71 SmoleS.Skoczylas.RakoczyR.Ledwoyw-SmoleI.Liszka-SkoczylasM.KopeA.et al