She discovered that the ER maintains its oxidized equilibrium by importing from the cytosol an oxidized form of glutathione called GSSG and exporting a reduced form called GSH
Oral glutathione largely fails because it breaks down in the gut before reaching circulation
Himmelfarb J, Ikizler TA, Ellis C, Wu P, Shintani A, Dalal S, Kaplan M, Chonchol M, Hakim RM (2014) Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial
Vitamin supplementation for 1 year improves mood
Do not use on injured or irritated skin
Prolonged treatment of neuroblastoma cell lines with standard chemotherapy agents, etoposide or doxorubicin showed increased levels and synthesis of GSH, increased expression of -glutamyl-cysteinyl ligase, and decreased depletion of GSH [58, 65]