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This extended use is considered off-label, which means: The medication is used beyond the FDA-approved duration The practice is legal It is often supported by clinical experience and emerging evidence Phentermine was originally approved in 1959, an era when long-term obesity trials were uncommon

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0.01% w/v sodium citrate 0.008% w/v, and benzyl alcohol 1.0% v/v (preservative).

10.20517/cdr.2021.20 117

10.1007/s11010-016-2861-4 151 LiuY.SunH.MakabelB.CuiQ.LiJ.SuC.et al (2019)

There is no specific age that is a contraindication, but GHK-Cu should not be used in children or adolescents as its effects on a developing body are not studied