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At the same time, those affected with Crohns often undergo surgeries that involve the removal of at least a portion of the terminal ileum, placing them at further risk for a vitamin B12 deficiency

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Furthermore, PPAR- can reduce the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), low density lipoprotein receptor (LDLR), and cytochrome P450 family 7 subfamily A polypeptide 1 (CYP7A1) via both dependent and independent pathways, disrupting the balance of cholesterol metabolism [78]

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