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Tirzepatide's labeling specifically advises using a barrier method or switching to a non-oral contraceptive for four weeks after starting and after each dose increase

Tirzepatide (Mounjaro) acts centrally to reduce appetite and slow gastric emptying

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Nature (2013) 496:1103

Propagation of pericentral necrosis during acetaminophen-induced liver injury: Evidence for early interhepatocyte communication and information exchange

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