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Permeation techniques: Microneedles and topical permeation enhancers have been studied to increase delivery, though translation to routine cosmetic use requires safety and regulatory evaluation (PubMed

Fourteen percent of participants had diabetic retinopathy at baseline (most mild non-proliferative), and the rates of retinopathy progression during the study were low (6% and 8% with orforglipron and 7% and 8% with semaglutide), with no significant difference between groups

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