does glp 1 help with diabetes GLP-1 Drugs and Type Diabetes: Less Insulin, Better Time in Range — What the Evidence GLP-1-based therapies for type 2

Fisfalen ME, DeGroot LJ, Quintans J, Franklin WA, Soltani K

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Like everything else in your body, it depletes with time, leaving us feeling sluggish and allowing for sickness and disease to enter

This was an observational, retrospective analysis meaning it looked backwards at existing patient data rather than prospectively testing a hypothesis under controlled conditions

NICE guidance recommends GLP-1 receptor agonists for type 2 diabetes when triple therapy is insufficient and specific BMI criteria are met, or for weight management in adults with BMI 30 kg/m (or 27 kg/m with comorbidities) through specialist services

Furthermore, the PI3K/Akt pathway interacts with AMPK signaling through TSC2-mediated regulation of mTORC1, creating a feedback loop that fine-tunes cellular energy homeostasis