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A 1mg/kg dose in a 0.25kg rodent translates to approximately 0.16mg/kg human equivalent dose when scaled allometrically

Recent work using single nuclear RNA sequencing and translating ribosome affinity purification sequencing showed that mHtt mediates the release of mitochondrial RNA which then binds to the innate immune sensor protein kinase R, resulting in the activation of innate immune signaling in the most vulnerable HD neurons: spiny projection neurons (Lee et al., 2020)

In non-toxic doses, the effects of caffeine are mediated by differential antagonism of A 1 and A 2A adenosine receptors

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It can be a learning curve to learn how to switch between your drawing needle and your injecting needle without pushing on the plunger