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GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )

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Natural Strategies vs GLP-1 Drugs The rise of GLP-1 drugs has been a major breakthrough for treating obesity and type 2 diabetes