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Itabe, H., Yamaguchi, T., Nimura, S

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It has been proposed that damage caused by ROS and RNS including HNE causes impaired glucose metabolism and electrochemical gradients across membranes which in turn affects calcium homeostasis (Butterfield and Halliwell 2019)

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(1) An interesting pathway in relation to this is the possibility of decreased levels of the antioxidant enzymes glutathione and paraoxonase, due to oxidative changes and cellular immunity at a genetically predisposed level