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5.4 New Treatment Approches for DPN Recent advancements in DPN treatment focus on both symptom management and addressing underlying nerve damage through innovative pharmacological, non-invasive and regenerative approaches

Differences in effectiveness for weight management The STEP clinical trial programme demonstrated that people using semaglutide 2.4 mg (Wegovy) lost on average around 15% of their body weight over 68 weeks

434 Patients with PDPN have increased epineurial blood flow and intravascular oxygen saturation, perhaps secondary to arteriovenous shunting due to sympathetic denervation

Several limitations should be acknowledged

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