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A UPLC-MS/MS Method for In Vivo and In Vitro Pharmacokinetic Studies of Psoralenoside, Isopsoralenoside, Psoralen and Isopsoralen from Psoralea Corylifolia Extract

FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology ( As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Zha et al., 2024

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The safest approach is to share the exact product label with your veterinarian and ask whether timing, dose, or monitoring should be adjusted

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