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Pi-Sunyer et al., 2015

Hot flashes, blood clots, and endometrial changes are common

The SURMOUNT-1 DXA substudy found that tirzepatide produced a 33.9% reduction in fat mass and a 10.9% reduction in lean mass over 72 weeks, with approximately 75% of total weight lost coming from fat and 25% from lean mass

Lyophilization, or freeze-drying, is a sophisticated process where the peptide is frozen, and then the surrounding pressure is reduced to allow the frozen water to sublimate directly from a solid to a gas