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Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus
It is generally understood that new biomarkers discovered after application of bioinformatics analysis of omics datasets should be verified using more focused forms of analysis
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Consequently, the development of kidney-specific antisense oligonucleotide (ASO) or adeno-associated viral (AAV) transduction methods is advantageous, as these approaches can selectively inhibit ANGPTL4 in proximal tubules, glomerular podocytes, and glomerular endothelial cells, thereby avoiding the adverse systemic effects associated with whole-body ANGPTL4 loss (Srivastava et al., 2024)
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