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This tripeptide combines cysteine, glycine, and glutamic acid, and exists at surprisingly high levels5 millimolarin most cells

The MTHFD1 encoded enzyme possesses three activities that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase