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Finally, a recent network meta-analysis that compared cognitive outcomes with various antidiabetic agents in patients with type 2 diabetes observed that GLP-1RAs ranked second after sodium-glucose cotransporter-2 inhibitors for reducing dementia risk

These symptoms typically appear shortly after treatment initiation or following a dose increase

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Here, we further find that genes contributing to glutamate homeostasis, e.g

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Brain microvascular endothelial cells express five carriers for the amino acid alanine belonging to two groups, neutral amino acid transporters (ASCT/SLC1A) or small neutral amino acid transporters (SNAT/SLC38A)