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*Note L-Citrulline is different than Citrulline Malate, which is L-Citrulline combined with malic acid

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Here, ascorbate resistant JLPR cells (that were generated by incubation of sensitive JLPS cells with increasing ascorbate concentrations from 0.1 to 1 mM over 6 months) were characterized not only by increased levels of genes such as ferritin, topoisomerase II and glutathione peroxidase 4, but also by the decreased expression of high-mobility group protein box 1 (HMGB1), one of the ligands of AGER