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OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

has been outspoken against the high costs and overuse of GLP-1s, preferring that people make lifestyle and behavioral changes instead

In clinical trials, more than 85% of individuals with fatty liver experienced liver fat reduced to healthy levels, and some experienced as much as 22 to 24 percent weight loss in less than a year

Accordingly, part of the elevated acylcarnitines is likely attributable to the effect of L-carnitine supplementation, which increases circulating acylcarnitine species

Vitamin E (Alpha-tocopherol)

[PubMed] Martinez G., Costantino G., Clementi A., Puglia M., Clementi S., Cantarella G., De Meo L., Matera M