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During this process, the HAMA solution or the HAMA solution containing GLP-1RAs@NPs or GLP-1RAs@NPs-WYRGRL will blend with the deionized water at the needle tips, thereby replacing the deionized water at the needle tips with the HAMA solution containing GLP-1RAs@NPs or GLP-1RAs@NPs-WYRGRL

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They are secreted in a reciprocal rhythm, influenced by the neuropeptide Y (NPY) system in the hypothalamus, which is acted upon by these afferent hormones