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In sepsis, pathophysiological changes include sympathetic nervous system activation, and excessive release of catabolic hormones (catecholamines and glucocorticoids) and pro-inflammatory cytokines

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Alternative diabetes medications include metformin (first-line treatment), SGLT2 inhibitors (such as dapagliflozin), and DPP-4 inhibitors (such as sitagliptin), each with different side effect profiles

The holistic side of its program has been on an extended hiatus, though aspects of it are available for prescription-based users

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